Week 1’s NFL All-Star offense and defense deliver a blueprint for fantasy success: Josh Allen powers the Bills’ 41-40 comeback with 394 passing yards and dual threat scores, while Derrick Henry and Saquon Barkley anchor the backfield. Puka Nacua, Zay Flowers and Jaxon Smith-Njigba headline the receivers, Brock Bowers shines at TE amid a Week 1 injury, and the O-line trio Alt-Membou-Vorhees-Goncalves with Erik McCoy paves the way. Defenders Myles Garrett, Nnamdi Madubuike, Ed Oliver and Nick Bosa pace the line, with Roquan Smith, Devin White and Harold Landry at LB and a sturdy secondary led by Adebo, Wright, Love and Curl. Special teams shine in Boswell, Cooke and Dike’s performances.

George Kittle lands on injured reserve with a hamstring in a tight 49ers schedule storm, four games in 23 days. Earliest return could be Oct. 12 at Tampa Bay if a four-week window holds. Jake Moody is waived after a misfire and a blocked kick as Eddy Pineiro visits for a potential replacement. With Kittle out, Luke Farrell and Jake Tonges step in at tight end, Kyle Juszczyk may see more inline TE duties, and Brayden Willis could be elevated from the practice squad if needed.

Moody’s shaky SF tenure and Pineiro’s visit add kicking uncertainty beyond Robbie Gould’s legacy. The Niners must navigate a grueling stretch against New Orleans, Arizona, Jacksonville and the Rams, while Purdy looks to sustain timing with a reshaped TE corps. Fantasy implications center on reduced Kittle volume early and how SF redistributes targets and red-zone chances during this heavy slate.

Seattle fell 17-13 to San Francisco in Week 1 after a dramatic late sequence. Julian Love blocked a field goal, keeping Seattle within reach, while Riq Woolen positioned for a potential game-sealing pick that Tonges stole for a TD with 1:34 left. Brock Purdy worked through heavy pressure and connected on the decisive end-zone throw to Tonges, but Sam Darnold later coughed a fumble in the Red Zone to seal the loss. The result stings in a division race opener and leaves fantasy managers eyeing the next matchup for Seahawks’ defensive and special-teams consistency.

Fantasy takeaways center on Seattle’s defense and the surprise breakout moment for Tonges, whose TD capped SF’s late surge. Seattle’s offense stalled in the red zone, and while Woolen had a rough finish, Love’s special-teams play remains a bright spot. Week 1 sets the stage for how Seattle might lean on its secondary and short-yardage opportunities as it eyes improvement against tougher opponents.

Jaxon Smith-Njigba, the Seattle Seahawks' standout wide receiver, has made waves with an impressive 2024 season, leading the team in receptions, yards, and touchdowns. With 100 catches for 1,130 yards and six touchdowns, he has firmly established himself as the WR1. His development has raised the excitement level among Seahawks fans and fantasy managers alike, as he continues to showcase his potential as a top-tier receiver in the league.

His performance has drawn attention from teammates and analysts, particularly regarding how his emergence opens up opportunities for fellow receivers. As Smith-Njigba thrives, the Seahawks’ offense becomes more dynamic and potent, emphasizing the importance of building around young talent. His ability to create separation and make contested catches perfectly complements quarterback Geno Smith's passing style.